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Approximately 64 of a 30-mg oral solution dose of paroxetine was excreted in the urine with 2 as the parent compound and 62 as metabolites over a 10 day post dosing period.
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The most commonly observed adverse events associated with the use of paroxetine incidence of 5 or greater and incidence for paroxetine tablets at least twice that for placebo, derived from table 4 were asthenia, sweating, nausea, dry mouth, diarrhea, decreased appetite, somnolence, libido decreased, abnormal ejaculation, female genital disorders, and impotence.
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If concomitant use of paroxetine hydrochloride controlled-release tablets with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases see allegra d online warnings serotonin syndrome .
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the concomitant use of paroxetine with maois intended to treat psychiatric disorders is contraindicated.